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A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Internal Medicine".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 9384
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Special Issue Editors
Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo 183-0054, Japan
Interests: cardiothoracic surgery; veterinary cardiology; echocardiography
Special Issues, Collections and Topics in MDPI journals
Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo 183-0054, Japan
Interests: veterinary internal medicine; veterinary cardiology; echocardiography; diagnostic imaging; biomarkers
Special Issue Information
Dear Colleagues,
Cardiovascular diseases are important cause of death in animals. Veterinary cardiology attracts the attention of many researchers in various veterinary institutions. In the past, this field of research was almost restricted to small animals; however, with the wide expanse of diagnostic facilities, the field has been widened to include various animal species under various physiologic and pathological circ*mstances. This is because of the introduction of recent diagnostic facilities which can be applied even under adverse conditions. This includes new echocardiographic methods which showed promising results to replace invasive diagnostic approaches, smartphone-based heart function monitoring facilities, biomarkers, and new cardioprotective therapies. In this special issue, original articles, systematic reviews, short communication, and case reports are welcome. Our research topic includes diagnostic techniques, disease models, clinical studies, laboratory markers, invasive methods, and new therapies in the cardiovascular area in laboratory models, companion animals as well as farm animals.
Prof. Dr. Ryou Tanaka
Prof. Dr. Ahmed S. Mandour
Guest Editors
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Keywords
- veterinary cardiology
- heart function
- echocardiography
- ECG
- interventional cardiology
- biomarkers
- cardiac dysfunction models
- smart technology
13 pages, 586 KiB
Open AccessArticle
Cardiovascular Effect of Epoprostenol and Intravenous Cardiac Drugs for Acute Heart Failure on Canine Pulmonary Hypertension
byYunosuke Yuchi, Ryohei Suzuki, Shuji Satomi, Takahiro Saito, Takahiro Teshima and Hirotaka Matsumoto
Vet. Sci. 2023, 10(4), 302; https://doi.org/10.3390/vetsci10040302 - 19 Apr 2023
Viewed by 1729
Abstract
Pulmonary hypertension (PH) is a life-threatening complication in dogs with cardiopulmonary disease. Epoprostenol is an intravenous pulmonary vasodilator used to treat PH in humans; however, its efficacy in dogs remains unknown. We investigated the cardiovascular effects of epoprostenol and several cardiac agents for [...] Read more.
Pulmonary hypertension (PH) is a life-threatening complication in dogs with cardiopulmonary disease. Epoprostenol is an intravenous pulmonary vasodilator used to treat PH in humans; however, its efficacy in dogs remains unknown. We investigated the cardiovascular effects of epoprostenol and several cardiac agents for acute heart failure in canine models of chronic PH. Six dogs with chronic PH were anesthetized and underwent right heart catheterization and echocardiography before and after infusion of epoprostenol, dobutamine, dopamine and pimobendane. (The drug administration order was the same for all dogs). High-dose epoprostenol (15–20 ng/kg/min) tended to decrease pulmonary arterial pressure (PAP) while significantly decreasing pulmonary and systemic vascular resistance and increasing left and right ventricular (LV and RV, respectively) function. Pimobendan significantly increased LV and RV functions without increasing PAP. Conversely, dobutamine and dopamine significantly increased LV and RV function as well as PAP. This study revealed the efficacy of epoprostenol in treating canine PH through its pulmonary and systemic vasodilating effects. Although catecholamines improve LV and RV function, they might worsen PH pathophysiology, and careful monitoring may be necessary when using these drugs. Pimobendan improved LV and RV function without increasing PAP; however, a stronger vasodilating effect was observed with epoprostenol.Full article
(This article belongs to the Special Issue Current and Future Advances of Cardiology in Veterinary Research and Clinical Practice)
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8 pages, 568 KiB
Open AccessCommunication
Plasma Chymase Activity Reflects the Change in Hemodynamics Observed after the Surgical Treatment of Patent Ductus Arteriosus in Dogs
byKazumi Shimada, Lina Hamabe, Miki Hirose, Momoko Watanabe, Aimi Yokoi, Aki Takeuchi, Yusuke Ozai, Tomohiko Yoshida, Shinji Takai, Denan Jin, Meric Kocaturk, Katsumi Uehara and Ryou Tanaka
Vet. Sci. 2022, 9(12), 682; https://doi.org/10.3390/vetsci9120682 - 08 Dec 2022
Cited by 2 |Viewed by 1304
Abstract
Chymase is a protease stored in mast cell granules that produces angiotensin II (ANG II) from angiotensin I (ANG I) and is associated with tissue injury, inflammation, and remodeling, especially involving the cardiovascular system. As cardiovascular events occur, chymase is activated by degranulation [...] Read more.
Chymase is a protease stored in mast cell granules that produces angiotensin II (ANG II) from angiotensin I (ANG I) and is associated with tissue injury, inflammation, and remodeling, especially involving the cardiovascular system. As cardiovascular events occur, chymase is activated by degranulation to the extracellular matrix. Although chymase has been suggested to be associated with cardiovascular disease progression, there are not enough reports in veterinary medicine. Patent ductus arteriosus (PDA) is a common congenital cardiac disease in veterinary medicine. Almost all cases of PDA can be treated surgically to prevent the development of congestive heart disease and/or pulmonary hypertension. The aims of the present study were to measure chymase activity before and after PDA occlusions, and to investigate the relationships between the congestive and hemodynamic states of PDA and chymase activity. In the present study, 17 puppies diagnosed with PDA were included and all puppies completely recovered to the level of healthy dogs. Chymase activity significantly decreased at 2 months after the operation, along with the echocardiography parameters of congestion. Therefore, plasma chymase activity may be useful as a novel predictor for understanding the hemodynamics of PDA in veterinary medicine.Full article
(This article belongs to the Special Issue Current and Future Advances of Cardiology in Veterinary Research and Clinical Practice)
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10 pages, 733 KiB
Open AccessArticle
Evaluation of Left Ventricular Function in Healthy Retrievers Using Standard and 2D Speckle-Tracking Echocardiography
byLina Hamabe, Kazumi Shimada, Ahmed S. Mandour, Tomohiko Yoshida, Miki Hirose, Hanan Hendawy, Hussein M. El-Husseiny and Ryou Tanaka
Vet. Sci. 2022, 9(10), 529; https://doi.org/10.3390/vetsci9100529 - 27 Sep 2022
Cited by 5 |Viewed by 1712
Abstract
Standard echocardiography is vital for the assessment of cardiac performance in healthy and diseased animals. Similarly, two-dimensional speckle-tracking echocardiography (2D-STE) is an advanced echocardiographic technique that is becoming increasingly important for the assessment of myocardial function. Breeds, age, and body weight (BW) are [...] Read more.
Standard echocardiography is vital for the assessment of cardiac performance in healthy and diseased animals. Similarly, two-dimensional speckle-tracking echocardiography (2D-STE) is an advanced echocardiographic technique that is becoming increasingly important for the assessment of myocardial function. Breeds, age, and body weight (BW) are known to be important factors affecting the echocardiographic parameters; therefore, the aim of this study was to evaluate the effect of breed, age, and BW on the echocardiographic parameters in three breeds of clinically healthy Retrievers. A total of 46 Retrievers, including 16 Flat-coated Retrievers (FR), 16 Golden Retrievers (GR), and 14 Labrador Retrievers (LR) were included in the study. The comparison of the breeds revealed significant differences in the LV wall thickness of FR and GR, although further analysis using MLR showed that the differences were most likely associated with BW, similarly to the other LV dimensions. Functional parameters, including ejection fraction, fractional shortening, and left-atrial-to-aortic ratio, were independent of breed, age, and BW. On the other hand, peak aortic blood flow velocity, trans-mitral rapid ventricular filling flow, and the ratio of trans-mitral rapid ventricular filling flow to atrial contraction were influenced by age. The 2D-STE-derived radial and circumferential strain parameters were independent of breed, age, and BW, except for global strain in the radial direction.Full article
(This article belongs to the Special Issue Current and Future Advances of Cardiology in Veterinary Research and Clinical Practice)
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